Takasaki Domain (高崎藩 Takasaki -han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Kōzuke Province (modern-day Gunma Prefecture), Japan. It was centered on Takasaki Castle in what is now part of the city of Takasaki, Gunma. Takasaki was ruled through most of its history by a junior branch of the Matsudaira clan.