Định Vương Nguyễn Phúc Thuần (1754–1777) was one of the Nguyễn lords who ruled over the southern portion of Vietnam from the 16th–18th centuries. The collapse of the house of Nguyễn lords intensified during Thuần's reign, many uprisings broke out throughout central part of Vietnam, including the Tây Sơn revolt; and the offensive of Trịnh lords from northern Vietnam. He tried to re-establish the Nguyễn lords' authority but unsuceeded. At last, he was captured and executed along with his followers and almost all family members by Tây Sơn rebel general Nguyễn Huệ in 1777.