Los aceites de pescado son aceites obtenidos a partir de los tejidos de algunas especies de peces. Para la alimentación humana se pueden obtener ya sea comiendo pescado o tomando suplementos. Los pescados que son especialmente ricos en los aceites que son beneficiosos para el organismo y son conocidos con el nombre de ácidos grasos omega-3 incluyen a la macarela, el atún, el salmón, el esturión, el mújol, la anchoa, las anchovetas, las sardinas, el arenque, la trucha y el menhaden. Proporcionan alrededor de 1 gramo de ácidos grasos omega-3 en alrededor de 3,5 onzas (100 gramos) de pescado.

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Fish oil is oil derived from the tissues of oily fish. Fish oils contain the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), precursors of certain eicosanoids that are known to reduce inflammation in the body, and have other health benefits. Nonetheless, fish oil supplement studies have failed to support claims of preventing heart attacks or strokes. The fish used as sources do not actually produce omega-3 fatty acids, but instead accumulate them by consuming either microalgae or prey fish that have accumulated omega-3 fatty acids. Fatty predatory fish like sharks, swordfish, tilefish, and albacore tuna may be high in omega-3 fatty acids, but due to their position at the top of the food chain, these species may also accumulate toxic substances through biomagnification. For this reason, the United States Environmental Protection Agency recommends limiting consumption (especially for women of childbearing age) of certain (predatory) fish species (e.g. albacore tuna, shark, king mackerel, tilefish and swordfish) due to high levels of the toxic contaminant mercury. Dioxin, PCBs and chlordane are also present. Fish oil is used as a component in aquaculture feed. More than 50 percent of the world's fish oil used in aquaculture feed is fed to farmed salmon. Marine and freshwater fish oil vary in contents of arachidonic acid, EPA and DHA. The various species range from lean to fatty and their oil content in the tissues has been shown to vary from 0.7% to 15.5%. They also differ in their effects on organ lipids. Studies have revealed that there is no relation between total fish intake or estimated omega−3 fatty acid intake from all fish, and serum omega−3 fatty acid concentrations. Only fatty fish intake, particularly salmonid, and estimated EPA + DHA intake from fatty fish has been observed to be significantly associated with increase in serum EPA + DHA. The omega-3 fatty acids in fish oil are thought to be beneficial in treating hypertriglyceridemia, although claims of preventing heart attacks or strokes have not been supported. Fish oil and omega-3 fatty acids have been studied in a wide variety of other conditions, such as clinical depression, anxiety, cancer, and macular degeneration, yet benefits in these conditions have not been verified.

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