El comedón, también conocido popularmente como espinilla o barro, es la eflorescencia primaria del acné. Un comedón surge cuando el canal del folículo adonde drena la glándula sebácea se obstruye debido a una excesiva producción de queratina (hiperqueratosis).

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A comedo is a clogged hair follicle (pore) in the skin. Keratin (skin debris) combines with oil to block the follicle. A comedo can be open (blackhead) or closed by skin (whitehead), and occur with or without acne. The word comedo comes from the Latin comedere, meaning "to eat up," and was historically used to describe parasitic worms; in modern medical terminology, it is used to suggest the worm-like appearance of the expressed material. The chronic inflammatory condition that usually includes both comedones and inflamed papules and pustules (pimples) is called acne. Infection causes inflammation and the development of pus. Whether or not a skin condition classifies as acne depends on the amount of comedones and infection. Comedones should not be confused with sebaceous filaments. Comedo-type ductal carcinoma in situ (DCIS) is not related to the skin conditions discussed here. DCIS is a non-invasive form of breast cancer, but comedo-type DCIS may be more aggressive and so may be more likely to become invasive.

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