Lipófilo es el comportamiento de toda molécula que tiene afinidad por los lípidos. En una disolución o coloide, las partículas lipófilas tienden a acercarse y mantener contacto con los lípidos. Por ejemplo, los jabones poseen una parte de la molécula hidrófila (y a su vez lipófoba) y otra lipófila (y a su vez hidrófoba).

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Lipophilicity (from Greek λίπος "fat" and φίλος "friendly"), refers to the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene. These non-polar solvents are themselves lipophilic (translated as "fat-loving" or "fat-liking")—the axiom that like dissolves like generally holds true. Thus lipophilic substances tend to dissolve in other lipophilic substances, while hydrophilic (water-loving) substances tend to dissolve in water and other hydrophilic substances. Lipophilicity, hydrophobicity, and non-polarity can describe the same tendency towards participation in the London dispersion force as the terms are often used interchangeably. However, the terms "lipophilic" and "hydrophobic" are not synonymous, as can be seen with silicones and fluorocarbons, which are hydrophobic but not lipophilic.

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