En medicina, el coma (del griego κῶμα o κωμα, que significa «sueño profundo») es un estado grave de pérdida de conciencia, que puede resultar de una gran variedad de condiciones incluyendo las intoxicaciones (drogas, alcohol o tóxicos), anomalías metabólicas (hipoglucemia, hiperglucemias), enfermedades del sistema nervioso central, ACV, traumatismo cráneo-encefálico, convulsiones e hipoxia. Las causas metabólicas son las más frecuentes.[cita requerida] El coma es por tanto un síndrome. En la Clasificación internacional de trastornos de la salud (ICD-10) se le asigna la letra "R" (síntomas y diagnósticos). El coma es una expresión de un fuerte trastorno de las funciones cerebrales y por tanto con peligro de muerte. El desarrollo (pronóstico) del paciente comatoso es dependiente de las enfermedades subyacentes y de la asistencia médica.

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Coma is a state of unconsciousness in which a person cannot be awakened; fails to respond normally to painful stimuli, light, or sound; lacks a normal wake-sleep cycle; and does not initiate voluntary actions. A person in a state of coma is described as being comatose. A distinction is made in the medical community between a coma and a medically induced coma, the former is a result of circumstances beyond the control of the medical community, while the latter is a means by which medical professionals may allow a patient's injuries to heal in a controlled environment. A comatose person exhibits a complete absence of wakefulness and is unable to consciously feel, speak, hear, or move. For a patient to maintain consciousness, two important neurological components must function. The first is the cerebral cortex—the gray matter that forms the outer layer of the brain. The other is a structure located in the brainstem, called reticular activating system (RAS).Injury to either or both of these components is sufficient to cause a patient to experience a coma. The cerebral cortex is a group of tight, dense, "gray matter" composed of the nuclei of the neurons whose axons then form the "white matter," and is responsible for perception, relay of the sensory input via the thalamic pathway, and many other neurological functions, including complex thinking. RAS, on the other hand, is a more primitive structure in the brainstem which includes the reticular formation (RF). The RAS area of the brain has two tracts, the ascending and descending tract. Made up of a system of acetylcholine-producing neurons, the ascending track, or ascending reticular activating system (ARAS), works to arouse and wake up the brain, from the RF, through the thalamus, and then finally to the cerebral cortex. A failure in ARAS functioning may then lead to a coma. The word is from the Greek κῶμα koma, meaning "deep sleep")

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