The secretariat of an organization is the department that fulfils its central administrative or general secretary duties. The term is especially associated with governments and intergovernmental organizations such as the United Nations, although some non-governmental organizations (for example, the International Organization for Standardization) also refer to their administrative department as their secretariat. The building or office complex that houses such a department may also be referred to as its secretariat or secretariat building. In some cases, the secretariat is not a bureaucratic organ, but one which includes a certain organization run by all its members who collectively help to organize the larger group, such as the secretariat of the International of Anarchist Federations, which is an office that rotates irregularly between its member Federations. The Zhongshu Sheng or simply the Secretariat was one department in the Three Departments and Six Ministries structure in the history of China.

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