Gangrena (del latín gangraena, y éste, a su vez, del griego γάγγραινα, [gángraina], que significa 'putrefacción'), es un término en medicina humana y veterinaria que se refiere a la muerte de las células de la piel acompañada de una decoloración característica y pérdida irreversible de este tejido.

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Gangrene (or gangrenous necrosis) is a type of necrosis caused by a critically insufficient blood supply. This potentially life-threatening condition may occur after an injury or infection, or in people suffering from any chronic health problem affecting blood circulation. The primary cause of gangrene is reduced blood supply to the affected tissues, which results in cell death. Diabetes and long-term smoking increase the risk of suffering from gangrene. Gangrene is not a communicable disease; it does not spread from person to person. The types of gangrene differ in symptoms, and include dry gangrene, wet gangrene, gas gangrene, internal gangrene, and necrotizing fasciitis. Treatment depends on the underlying cause, and can include resection, debridement (or, in severe cases, amputation) of the affected body parts, antibiotics, revascularization (via a vascular bypass or angioplasty), or hyperbaric oxygen therapy. It can rarely include medical therapy to stop vascular spasm or the production of cold-induced vascular obstruction by cold-precipitated cryoglobulins.

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