En bioquímica, ligasa (del latín lig(āre) “juntar”, “unir”) son aquellas enzimas que catalizan la unión de dos moléculas a partir de la formación de enlaces covalentes acompañado por la hidrolisis del ATP.

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(This article is about general ligases. For DNA specific ligases, see DNA ligase.) In biochemistry, a ligase is an enzyme that can catalyze the joining of two large molecules by forming a new chemical bond, usually with accompanying hydrolysis of a small pendant chemical group on one of the larger molecules or the enzyme catalyzing the linking together of two compounds, e.g., enzymes that catalyze joining of C-O, C-S, C-N, etc. In general, a ligase catalyzes the following reaction: Ab + C → A–C + b or sometimes Ab + cD → A–D + b + c + d + e + f where the lowercase letters signify the small, dependent groups. Ligase can join two complementary fragments of nucleic acid and repair single stranded breaks that arise in double stranded DNA during replication.

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