The Punic Wars were a series of three wars fought between Rome and Carthage from 264 BC to 146 BC. At the time, they were probably the largest wars that had ever taken place. The term Punic comes from the Latin word Punicus (or Poenicus), meaning "Carthaginian", with reference to the Carthaginians' Phoenician ancestry.The main cause of the Punic Wars was the conflicts of interest between the existing Carthaginian Empire and the expanding Roman Republic. The Romans were initially interested in expansion via Sicily (which at that time was a cultural melting pot), part of which lay under Carthaginian control. At the start of the first Punic War, Carthage was the dominant power of the Western Mediterranean, with an extensive maritime empire. Rome was a rapidly ascending power in Italy, but it lacked the naval power of Carthage. By the end of the third war, after more than a hundred years and the loss of many hundreds of thousands of soldiers from both sides, Rome had conquered Carthage's empire, completely destroyed the city, and become the most powerful state of the Western Mediterranean. With the end of the Macedonian Wars – which ran concurrently with the Punic Wars – and the defeat of the Seleucid King Antiochus III the Great in the Roman–Seleucid War (Treaty of Apamea, 188 BC) in the eastern sea, Rome emerged as the dominant Mediterranean power and one of the most powerful cities in classical antiquity. The Roman victories over Carthage in these wars gave Rome a preeminent status it would retain until the 5th century AD.