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Meaning
  1. 1
    English · JMdict
    medicine scirrhus;scirrhous carcinoma
  2. 2
    English · Wikipedia

    Linitis plastica, also known as Brinton's disease or leather bottle stomach, is a morphological variant of diffuse (or infiltrating) stomach cancer. Causes of linitis plastica could be lye ingestion or metastatic infiltration of the stomach, particularly breast and lung carcinoma. It is not associated with H. pylori infection or chronic gastritis. The risk factors are undefined, except for rare inherited mutations in E-cadherin, which are found in about 50% of diffuse-type gastric carcinomas. This cancer (and most other stomach cancers) is more common in Asian countries, particularly Japan.

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