The Sienese School of painting flourished in Siena, Italy between the 13th and 15th centuries and for a time rivaled Florence, though it was more conservative, being inclined towards the decorative beauty and elegant grace of late Gothic art. Its most important representatives include Duccio, whose work shows Byzantine influence; his pupil Simone Martini; Pietro and Ambrogio Lorenzetti; Domenico and Taddeo di Bartolo; Sassetta and Matteo di Giovanni. Unlike the naturalistic Florentine art, there is a mystical streak in Sienese art, characterized by a common focus on miraculous events, with less attention to proportions, distortions of time and place, and often dreamlike coloration. In the 16th century the Mannerists Beccafumi and Il Sodoma worked there. While Baldassare Peruzzi was born and trained in Siena, his major works and style reflect his long career in Rome. The economic and political decline of Siena by the 16th century, and its eventual subjugation by Florence, largely checked the development of Sienese painting, although it also meant that a good proportion of Sienese works in churches and public buildings were not discarded or destroyed by new paintings or rebuilding. Siena remains a remarkably well-preserved Italian late-Medieval town.

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